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Published online November 23, 2015:1-5

Rosenfeld et al., Cell, 68:143-155 (1992)

HDACs and SIRTs, by removing lactylation modifications, regulate the levels of lactylation in the CNS together with the writers

While this reaction was traditionally viewed as a minor nicotinamide clearance pathway, research has revealed that NNMT activity has far-reaching consequences for cellular metabolism through multiple interconnected mechanisms