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Everywhere else, for patient data, two-sided paired t tests were carried out, while for in vitro data, it was subjected to unpaired two-sided Student t tests, always with a p value of 0.05 as the cutoff for significance

[14] The European Food Safety Authority has set an Acceptable Daily Intake of 0.2 mg per kg body weight, as of 2019

doi: 10.3389/fendo.2013.00052 11 GagginiMSaponaroCGastaldelliA

To unequivocally establish ozone therapy standing as an efficacious knee OA treatment, there is an undeniable need for comprehensive, multicentre RCTs with extended follow-ups to corroborate its long-term benefits and reliability