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Zinc, copper, and manganese serve as cofactors in collagen production enzymes

Severe cramps, not responding to stretching or pain medications, or associated with severe dehydration from over-exertion or illness (severe vomiting and/or diarrhea), may need treatment with intravenous (I.V.) fluids and electrolytes

Increasing age Having family members with vein problems Hormonal changes during puberty, pregnancy, and menopause, or from birth control pills Increased amount of blood and pressure of the expanding uterus during pregnancy Obesity, leg injury, prolonged standing, and other things that weaken vein valves Why do varicose veins and spider veins appear