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Should these substances enter the bloodstreama real risk considering increased gut permeabilitythey can trigger an inflammatory response, Jandes explains

In addition, it should be used with great caution if at all when there is preexisting liver disease

For chelators, such as DFO, which has a short plasma half-life and therefore requires frequent doses, the IN route provides a safe and efficacious delivery method with higher patient compliance

Children aged 4 and older may be considered in specific medical situations, while teenagers and adults should follow age-appropriate dosing guidance to ensure safety and efficacy