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Bilateral lesions from 6-OHDA injections in the MFB produce dose-dependent, extensive retrograde degeneration of DA neurons in the SNc that can be quite severe leading to bradykinesia, changes in gait and nociception, cognitive deficits, depressive-like behavior, and enteric nervous system dysfunction [29]

3.3 Changes in gut microbial composition in Psoriasis Gut microbiome in all states (HCs, PSO) consisted of four dominant phyla: Firmicutes , Proteobacteria , Actinobacteriota , and Bacteroidota ( Figures 3A, B )

Although natural bioactive compounds show considerable promise in promoting post-ischemic stroke recovery, several translational and clinical challenges must be addressed