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This differential role depends on their ability to confer different properties to adrenergic 2A receptor ( 2A R)-D 4 R heteromers and dopamine D 2 receptor (D 2 R)-D 4 R heteromers, preferentially localized in the perisomatic region of the frontal cortical pyramidal neuron and its striatal terminals, respectively

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References Lamptey RNL, Chaulagain B, Trivedi R et al (2022) A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of nanotherapeutics

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