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Interestingly, we have reported that intranuclear localization of AIF involves in the peroxynitrite-induced apoptosis of SGNs (Liu et al., 2012), whether GPX1 regulates the intranuclear localization of mitochondrial AIF to alleviate apoptosis in SGNs after peroxynitrite injury deserved further exploration

I dont have PA but its very likely that I have a genetic issue with processing vitamin B12 and breaking it down into the methyl and adenosylcobalamin forms (my mom and I both have constantly elevated methylmalonic acid and symptoms of B12 deficiency despite normal serum B12 levels)

1B), as defined in the methods