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Some new candidate genes will probably be identified serendipitously through gene targeting in the mouse, but a more directed strategy might begin with examination of logical candidates, such as the fibril-associated proteins

Intriguingly however, very recent data on anti-CD20 B cell depleting agents might be showing some efficacy in progressive MS, although the effect of peripheral B cell depletion on PIRA cannot be interpreted as independent of its effect on silencing acute/adaptive inflammatory activity (Kappos et al., 2020)

The gene expression changes the peptide triggers may be more important than continuous peptide presence