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Overall, our present study demonstrated that ROS induces GCLC desuccinylation and consequent activation through enhancing its interaction with desuccinylase SIRT2, which represents an essential mechanism for cancer cells to evade oxidative stress-induced ferroptosis, and constitutes a potential target for clinical cancer treatment

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recurrentis A17 were kindly provided by Reinhard Wallich (emer.), Institute of Immunology, University of Heidelberg, Germany

I use lower amounts of pre-fermented flour for retarded and higher amounts for ambient