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Regulatory-wise, Semaglutide has gained FDA approval for specific indications, including type 2 diabetes [10] and chronic weight management [11]

The intracellular metabolic adjustment is neutralized by the overexpression of a monocarboxylate transporter (MCT), resulting in a H + -linked co-transport of lactic acid across the plasma membrane, with increased extracellular acidity, known as lactic acidosis (Figure 1)