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Consistent with HeLa cell experiments, mitochondrial iron levels were significantly reduced in HMOX2 KO C2C12 cells compared to WT C2C12 cells, and re-expressing HMOX2 WT in HMOX2 KO cells restored iron levels, but not in cells re-expressing the HMOX2 K68R mutant (Fig

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An inverse correlation between miR-142 and SIRT1 expression was observed in the brains of long-lived aged rhesus macaques ( In astrocytes, epigenetic regulations in their senescence remains under investigation (Labarta-Bajo and Allen, 2025), while several studies have reported the histone acetylation and increased H3K27ac enrichment in AD astrocytes Li X