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These findings indicate that PlexinB1 and PlexinB2 have a role in the inactivation of RanGTP

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Prior studies in cancer cell lines showed that ABHD11 deficiency leads to 2-OG accumulation, which drives the formation of the l-enantiomeric ( S) form of 2-hydroxyglutarate (2-HG) and subsequent inactivation of 2-OGDDs involved in the HIF pathway (prolyl hydroxylases, PHDs), histone marks (for example, lysine demethylases, KDMs) and DNA methylation (for example, ten-eleven translocation,TET enzymes) 16,22,23

That said, avoid using very high concentrations (1520%) unless prescribed by a dermatologist, as they may irritate skin without any benefits