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Safety Comparison Summary# Practical Considerations# Availability and Formulation# Both Dihexa and PE-22-28 are available only as research chemicals from peptide suppliers

The proportions of M1M6 and [ 3 H]BPC157 in plasma radioactive components at different sampling times demonstrated that [ 3 H]BPC157 was the main plasma component at 0.05 h (3 min) after administration and was subsequently degraded into small molecular peptide fragments in the following 0.167 h (10 min) (Figure 5A)

Skipping doses or discontinuing treatment prematurely may affect the desired outcomes

Skin Repair Pathways MMP/TIMP, Collagen & Elastin (PMC, 2015) A focused review of GHK as a modulator of multiple skin regeneration pathways published in PMC confirmed that GHK-Cu stimulates both synthesis and breakdown of collagen and glycosaminoglycans, and modulates the activity of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs)