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2018;42(Suppl 1):S22833

Whether injected NAD+ meaningfully improves energy or aging in healthy adults is an open research question, and results vary from person to person

This is quite possible as activation of molecular oxygen could result in the formation of mostly superoxide, from which H 2 O 2 and hydroxyl radical could be formed.[] The DNA-nonspecific, highly reactive hydroxyl radical, even at very small levels, would inflict mutations facilitating resister generation

Medical therapy & topicals: tyrosinase inhibitors such as azelaic acid, arbutin, niacinamide, retinol, liquorice root extract, botanicals, cysteamine, & novel blockers