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Pickart completed a 2008 study proving copper tripeptides can trigger collagen and elastin synthesis

By targeting the aforementioned pathways, it might be possible to achieve targeted therapy for DUs while sparing healthy patient cells, yielding more precise and effective treatments to alleviate the suffering of patients with these ulcers

The absence of specific probiotics, especially those that produce IPA(such as Faecalibacterium prausnitzii ) and I3A-producing lactobacilli , leads to depletion of protective metabolites, resulting in decreased levels of IPA and I3A, insufficient AHR activation, weakened intestinal barrier function, and exacerbated immune imbalance (Huang et al., 2023

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