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Others describe a persistent tightness or a constant feeling of something lodged in the throat, even though nothing is present

WillsABSpauldingABAdjemianJPrevotsDRTurkSPWilliamsCet al

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To compensate for the increased effective thickness and reduced contrast at higher tilt angles, we applied tilt-dependent dose weighting, based on a cosine correction model implemented in SerialEM, increasing the total dose per tilt at steeper angles proportionally to the apparent path length of the electron beam through the specimen