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Together, these results suggest GSH homeostasis is compromised in senescent cells, by a decrease in synthesis, an increase in degradation, and/or reaction with oxidative species

Auflage, 2021 European Medicines Agency (EMA): Opzelura (ruxolitinib), unter: www.ema.europa.eu (Abrufdatum: 12.03.2024) European Medicines Agency (EMA): Scenesse (afamelanotide), unter: www.ema.europa.eu (Abrufdatum: 12.03.2024) Fritsch, P

However, mutant variants such as A53T bind to the lysosomal receptor LAMP2A but fail to translocate into the lumen, resulting in a blockage that impairs not only their own degradation but also that of other CMA substrates [171, 172]