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These statements have not been evaluated by the FDA Sources:

USP7 itself is negatively regulated by MAGEL2, an E3 ligase mentioned above which is highly expressed in the SCN and associated with sleep disorders and circadian rhythm disruptions in both humans and mice (Kozlov et al., 2007

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Thus, our study provides additional substantiation for the appropriateness of this model in simulating the environment wherein the replanted grafts reside post-transplantation, and investigating the mechanisms governing cell death