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induced chronic liver injury and hepatic encephalopathy in male BALB/c mice (79 weeks old) through intraperitoneal injection of thioacetamide (200 mg/kg, 3 times per week) (Zhao et al., 2021)

Currently, GPx3 is considered a new tumor-suppressor gene [23], and its hypermethylation, which is associated with the further down-regulation of GPx3, was observed in patients with Barretts esophagus [54], endometrial adenocarcinoma [55] and prostate cancer [56]