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The combination of these two optimized structures offers several practical advantages over native hormone combinations: enhanced intrinsic potency means lower doses may be required to achieve equivalent effects, improved proteolytic stability extends duration of action compared to native peptides, preserved selectivity avoids unwanted endocrine effects, and the complementary optimization strategies (helix stabilization for GHRH, selective receptor activation for GHRP) address different aspects of the synergistic interaction

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