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Is there evidence for this and is it safe

When TLR4 is activated by bacterial LPS or by molecules from injured cells, it triggers a cascade of events that causes the cell to produce inflammatory cytokines.[ref] LDN is thought to block the activation of TLR4, thus reducing the release of inflammatory cytokines such as TNF-alpha, IL-6, and IL-12.[ref] LDN is one of the few TLR4 antagonists that can cross the blood-brain barrier.[ref] An animal study of multiple sclerosis found that naltrexone prevents the learning and memory issues associated with neuroinflammation

Shigematsu, N

[DOI] [PubMed] [Google Scholar] 69.Baczyk M., Ruchaa M., Pisarek M., Pietz L., Wrotkowska E., Wojewoda-Korbelak M., Dziubandowska A., Gembicki M., Sowiski J