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Mendoza Mar Y, Fernndez Mayola M, Aguilera Barreto A, Garca Ojalvo A, Bermdez Alvarez Y, Mir Bentez AJ, Berlanga Acosta J

Preferably, at least 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 60, or 70% of the amino acid-comprising conjugation partner is converted to the compound of formula (IB)