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Introduction Hyperpigmented macular freckling can occur as a single lesion (lentigo simplex) or as multiple lesions (benign vulvar melanosis)

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These comparative studies establish the pharmacological basis for the different biological profiles of MT-1 versus MT-II , with MT-1s MC1R preference explaining its predominantly pigmentary and skin photoprotection biology in contrast to MT-IIs broader melanocortin receptor activation producing pro-sexual, pro-erectile, and central appetite effects alongside pigmentation

Additionally, 87% of participants were not using oral contraceptives at baseline