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In their role as primary immune cell of the CNS, they are crucial for maintaining a clean microenvironment by preventing the accumulation of cellular debris and metabolic waste products

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Complex I (NADH: ubiquinone oxidoreductase) is the primary entry point of electrons into the respiratory chain, passing reducing equivalents from NADH to CoQ 46

GPx4 mRNA and protein expression were detected in various areas of the brain such as pyramidal neurons of the frontal and entorhinal cortex, dentate granule cells and CA pyramidal neurons in the hippocampus of embryonic rat brains but not in glial cells (Savaskan et al., 2007)