half life of reduced glutathione L-Glutathione Glutathione Redox cycle. Abbreviations. GSSG:

(SEE BELOW FOR UPDATE) Results from the second round are even more compelling Round 2 (2024) Duration: 12 weeks Participants: eleven firefighters (a mix of full-time and volunteers) from two local agencies Testing: Same as Round 1 Key takeaways The total number of high-range (95th percentile) toxins across all participants decreased 81.4% The total number of high-range mycotoxins (molds) decreased 86.7% The total number of high-range environmental toxins decreased 85.1% The total number of high-range environmental toxins decreased 85.1% According to preliminary data, the total number of high-range PFAS chemicals across all Round 2 participants decreased by 80% (A 2023 article from the Harvard Public School of Health explains that PFAS are known as forever chemicals because they dont break down in the environment or in our bodies . A report from the United States Navy states that there is no recommended medical treatment to reduce PFAS in the body. We hope to shift this narrative.) Case studies from Round 2 Case study #1 Participant started with 16 toxins in the 95th percentile and 17 toxins in the 75th

For the GSSCys assays, either GSH was varied between 50 M and 2.0 mM at fixed GSSCys concentrations (25, 50, 100 and 150 M) or GSSCys was varied between 25 and 200 M at fixed concentrations of GSH (0.05, 0.1, 0.2, 0.3 and 1.0 mM for ScGrx7 or 0.3, 0.5, 1.0 and 2.0 mM for PfGrx)

Side Effects: Sedation Fatigue Depression (suicidal tendencies) Parkinsonism symptoms Hypotension Bradycardia Chest pain Gastric ulceration Diarrhea & vomiting Dry mouth Syncope & arrhythmias For more see Cheung & Parmar (2022) Pharmacokinetics: Reserpine readily crosses the blood brain barrier & depletes cerebral catecholamine stores

Psychiatry 21, 738748