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It is important to note that a seizure can begin as a focal seizure, in one part of the brain, and progress to a generalized seizure, affecting both sides of the brain

(3) Current ferroptosis inhibitors (e.g., Ferrostatin-1) exhibit limitations such as low blood-brain barrier penetration and poor tissue specificity, while clinically used iron chelators (e.g., deferoxamine) may interfere with physiological iron homeostasis

Nanoemulsions can be engineered to possess specific properties, such as size, surface charge, and stability, rendering them highly versatile and effective in different applications

Therefore, the therapeutic strategy of inhibiting ferroptosis in CAG through low-toxicity TCM and natural molecular compounds has potential