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Moreover, TMAO increased the expression and activity of tissue factor (TF) via activation of the NF-B signaling pathway in primary human coronary artery endothelial cells (HCAECs), thereby promoting atherothrombosis (Cheng et al., 2019)

The PGPRs affect plant metabolisms by acting on several mechanisms, including the production of exopolysaccharides, plant hormones, and carotenoids, nitrogen fixation, siderophore, amplified light and CO 2 fixation rates, improved root and shoot system in response to drought stress, They also help in the development of induced systemic tolerance (IST) (Langeroodi et al

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The FDA warns persons with the following conditions should not use this drug: coronary heart disease, uncontrolled high blood pressure, hyperthyroidism, who have a history of drug abuse, pregnant women and nursing mothers