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Pediatr Nephrol 5(4):539544 Ding H, Gao XL, Hirschberg R, Vadgama JV, Kopple JD (1996) Impaired actions of insulin-like growth factor 1 on protein synthesis and degradation in skeletal muscle of rats with chronic renal failure

IGF-1 activates mTOR (mechanistic target of rapamycin) signaling in muscle tissue, promoting protein synthesis, and activates hormone-sensitive lipase in adipocytes, accelerating lipolysis

Reducing preneoplastic foci in NAFLD-related carcinogenesis, fibrosis-linked oncogenic signaling, and oxidative DNA damage can chemoprevent HCC (3034)