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doi: 10.1016/j.molmet.2018.06.004 80 CaoWLiMWuTFengFFengTXuYet al

they aren't strictly required by the pharmacology

These stresses disrupt physiological, biochemical, and metabolic processes, cause oxidative stress, and result in the excessive build-up of reactive oxygen species (ROS), including hydrogen peroxide (H 2 O 2 ), superoxide anion (O 2 - ), hydroxyl radical (OH), and singlet oxygen (O 2 ) (Sachdev et al., 2021