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For reconstitution and storage, the co-lyophilized blend should be treated with the same care as TB-500 (the more fragile component)

13 Photoaged skin appears lax and dry with wrinkles, deep furrows, tactile roughness, pigment irregularity, erythema, atrophy, and telangiectasia

the original rodent study used 5 mg/kg, which when scaled allometrically to human equivalents suggests doses in the 5-10 mg range for a 70 kg adult, though allometric scaling from mice to humans is an imprecise science

Most people get enough B12 from their diet, but many have absorption issues that mean adequate intake doesnt translate into adequate cellular levels