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Insulin and insulin-like growth factor-1 receptors Act as ligand-specific amplitude modulators of a common pathway regulating gene transcription

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Despite these differences, convergent functional outcomes have been reported, such as restoration of follicle numbers, normalization of estrous cyclicity and hormone profiles, reduced granulosa cell apoptosis, and improved ovarian architecture, frequently associated with activation of pathways including PI3K/AKT or SMAD signaling (He et al., 2024, Huang et al., 2018, Yang et al., 2019)