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doi: 10.3390/molecules28020835 174

The sciatic nerve is made up of the lower lumbar and sacral spinal nerves, which leave the spine and join to form the sciatic nerve

5-amino-1MQ, an analogue from our initial series of NNMT inhibitors with low IC50 value (IC50=1 M), and high cell membrane permeability (Table 5), produced the greatest reduction of intracellular 1-MNA levels at a concentration of 10 M among tested inhibitors