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The table below organizes the practical differences

Patients with a history of cobalt allergy may be at increased risk, as all cobalamins (including hydroxocobalamin and cyanocobalamin) contain a cobalt atom in their molecular structure

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Structural differences: In AHK-Cu (Ala-His-Lys:Cu(II)), the alanine methyl group introduces greater lipophilicity and steric bulk near the N-terminal copper coordination site