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1 Introduction Potassium dysregulation or abnormal potassium metabolism is common in patients with cardiovascular disease in the emergency setting due to the widespread use of diuretics ( The pharmacokinetics of potassium in humans is Unusual ( in vivo and their absorption was hard assessed by conventional plasma pharmacokinetics (PK), the US FDA recommends the use of urinary PK parameters (e.g., maximal excretion rate, Rmax, and cumulative excretion over 24 h, Ae0-24 h) as the criteria for bioequivalence (BE) evaluation