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When NNMT depletes SAM in adipocytes, epigenetic regulation is disrupted potentially locking in gene expression patterns that favor energy storage over expenditure

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(-)-Vestitol, Salviolone, and their combination reduced the A plaque burden and toxic soluble A levels in APP/PS1 transgenic mice We examined A deposition in the cortex and hippocampus of the mice

The FDA's decision to grant orforglipron a Commissioner's National Priority Review Voucher further accelerated the regulatory timeline, potentially compressing the standard 10-12 month review period to as little as 1-2 months