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Propafenone promotes mitochondrial HMOX1 expression by activating JNK/JUN signal, induces iron accumulation and ROS eruption, works together with RSL3 to promote ferroptosis in melanoma, Similarly, the CDK4/6 inhibitor palbociclib enhances the efficacy of the ferroptosis inducer auranofin by inducing cell senescence and depleting glutathione (GSH) and NADPH, This suggests that metabolic interventions as a strategy to overcome melanoma heterogeneity ( 6.2 Amplify the therapeutic effect of melanoma by combined targeting of ferroptosis and immune activation Multiple nanoplatforms combine the two functions of metabolic control and immune modulation

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