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Graham MR, Evans P, Davies B, Baker JS (2008) Arterial pulse wave velocity, inflammatory markers, pathological GH and IGF states, cardiovascular and cerebrovascular disease

Sublingual administration, which bypasses the gastrointestinal tract, appears to be equally effective as IM injections while being less invasive and more cost-efficientparticularly in patients with atrophic gastritis, post-gastrectomy status, or conditions that impair intrinsic factor-mediated absorption, where long-term intervention is often required

If the root problem is not treated, taking supplements alone may not give long-term benefits

Youll likely notice improvements in memory and concentration gradually, but some neurological effects might persist longer