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As a water-soluble vitamin, any excesses the body does not need are simply excreted in the urine

Here to Bust Myths & Misinformation The following is taken directly from the article Is It True That Cows Need Supplemental Vitamin B12

Rotate injection sites to prevent tissue damage and maintain optimal absorption

It was not until a genetically engineered strain of Pseudomonas denitrificans was used, in which eight of the genes involved in the biosynthesis of the vitamin had been overexpressed, that the complete sequence of methylation and other steps could be determined, thus fully establishing all the intermediates in the pathway