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By incorporating cells that retain the molecular and functional features of the native tissue, these platforms allow researchers to reproduce patient specific disease mechanisms and treatment responses in vitro

M.RajaM.KahangiF

In this case, supporting small and sustainable changes to lifestyle can still yield important improvements, but additional therapeutics are often still necessary to address the detrimental chronic presence of NAFLD

At the cellular interface, dermal fibroblasts regulate spreading, migration, and extracellular matrix (ECM) turnover through integrin-dependent adhesion signaling (e.g., FAK/ERK pathways), which is central to fibroblastECM homeostasis [48]