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Description

A novel natural siderophore antibiotic conjugate reveals a chemical approach to macromolecule coupling

Heidari et al

Using fluorescence polarization binding assays, we found that SERF2 binds with sub-micromolar affinities to various RNA sequences that are known to fold into rG4 structures 3,44 , including polyG, (GGGA) 4 , (GGA) 7 , (G4C2) 4 and (AGG) 5

Lee HK, Vaporciyan AA, Cox JD, Tucker SL, Putnam JB, Ajani JA, Liao Z, Swisher SG , Roth JA, Smythe RW, Walsh GL, Mohan R, Liu HH, Mooring D, Komaki R