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In addition, the enhancement of FAO can be mediated by G protein-coupled bile acid receptor TGR5 agonists and accompanied by an increase in mitochondrial superoxide dismutase 2 (SOD2) activity, which reduces oxidative stress and lipid accumulation in the podocytes thereby attenuating the DKD injury [70]

The early mortality of non-fasted mice seemed to result from more progressed hepatocyte necrosis accompanied by extensive hemorrhage in the surrounding tissue (Fig