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Sinularin induces DNA damage, G2/M phase arrest, and apoptosis in human hepatocellular carcinoma cells

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Most of the clinical studies [67-69] in humans where melatonin has been administered as a therapeutic adjuvant have been carried out on patients with an advanced stage of cancer, with metastasis and without response to conventional treatments

Two of these pathways involve the addition of highly water-soluble structures: glucuronate via the glucuronide pathway or sulfate via the sulfation pathway

Further research is needed to optimize their dosing and explore the synergistic effects of combined treatments to improve bladder health (Najmanov et al., 2019