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Nanoparticle-mediated lipid metabolic reprogramming of t cells in tumor microenvironments for immunometabolic therapy

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Of note, preventing the accumulation of p19 ARF -positive cells, another tumor suppressor that regulates p53 stability did not delay or prevent age-related pathologies ( FIGURE 3 In humans, peripheral blood T lymphocytes exhibit increased expression of p16 INK 4 a with age, tobacco smoking and physical inactivity