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Several preclinical studies showed that intranasal insulin treatment leads to an improvement in mitochondrial functions as well as a reduction of dopaminergic cell death in a rat 6-OHDA model of PD [197, 198]

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doi 10.1158/1538-7755.disp25-c053

Despite its importance for the maintenance and regulation of nerve cells, red blood cells, and the immune system, copper in a toxic form might serve as a stress agent for fish, inhibiting several biological functions and causing some histopathological alterations [27]