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The differences in the trypomastigote proteomic profiles were expected due to their environment, and huge number of stage-specific proteins in bloodstream forms, probably triggered by the exposure to the host immune system reinforces the necessity for drug validation on this developmental form

An earlier study has shown that -Klotho plays a significant role in the development of oocytes by aiding maturation through the activation of wingless-related integration site (Wnt) signaling pathways (Kim et al

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