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Specifically, IRE enhances systemic antitumor T-cell activation while downregulating immunosuppressive mechanisms in localized disease, promoting tumor antigen-specific expansion of tissue-resident memory CD8 + T cells (TRM) for durable immune surveillance (59)

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Collectively, these findings suggest that inflammatory signaling and chronic stress can directly impair BDNF trafficking, which contribute to the pathophysiology of MDD, although further study is needed to elucidate the underlying mechanisms

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