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Approaches for enhancing oral bioavailability of peptides and proteins

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(v) Molecularly targeted nanoparticles irradiated by picosecond pulsed laser to reversibly open the BBB and deliver drugs to brain tissue, specifically by synthesizing a gold nanoparticles (AuNPs) that are specifically targeted intravenously to tight junctions (TJs) on the BBB, followed by cranial picosecond laser stimulation to increase BBB permeability, a strategy that allows immunoglobulin and viral gene therapy vectors and drug-laden liposomes to enter the brain, and a process that is reversible and does not result in spontaneous vascular diastole or significant disruption of the structure of the neurovascular unit ( TABLE 2 Advantages and disadvantages of drug delivery methods