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The nuclear genome encodes most of the subunits of the enzyme complexes, assembly proteins and many of the factors necessary for mitochondrial DNA (mtDNA) replication, transcription and translation

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In addition to blocking coactivator binding, H12 repositioning allows the recruitment of corepressors such as nuclear receptor co-repressor 1 (NCoR) and silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) (PDB: 1KKQ) (Figure 4D) 93

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