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519 Additionally, inhibitors of HDAC11 are found to attenuate the self-renewal capacity of lung adenocarcinoma stem cells and overcome resistance to chemotherapy agents by downregulating Sox2, thereby offering novel pathways for enhancing the efficacy of cancer treatments 520 (Fig

The plate was heated from 25C to 95C with a rate of 0.033C/second

a , The FAT (residues 12551453 are omitted) and kinase domains of the apo, soluble, intermediate, and fully active states of mTOR are shown side by side