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Fatigue is one of the most common and debilitating symptoms across autoimmune diseases

CCK-8 assay revealed that RAW 264.7 macrophages treated with 400 g/mL Se/LDH@PEG-M for 48 h exhibited significant suppression of cell proliferation, while concentrations at or below 200 g/mL showed no apparent cytotoxicity during a 72-hour exposure period (Fig

30, 233241 10.1080/10641960802068725 [DOI] [PubMed] [Google Scholar] 56.Weigle N

However, when compared with the canonical heme binding pocket defined by heme degrading ABM domains 52,53 , the equivalent ArqI structure would be too small to accommodate such a large molecule without dramatic structural rearrangements